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Oncology

Combining classic and cutting-edge in vitro and in vivo research to support drug discovery efforts for cancer treatment.

Home Services & Solutions Services & Solutions Oncology CDX

CDX

Overview of CDX Models
Cell line-derived xenograft (CDX) models are preclinical tools in oncology that involve implanting human cancer cell lines into immunodeficient mice. Scientists study these tumors to assess their response to potential cancer therapies in a living organism.

BioDuro's CDX tumor models are used primarily in drug efficacy studies, providing reproducible and cost-effective solutions for efficacy testing and drug screening in cancer research. We have more than 300 CDX models available, covering 20+ human cancer types. Additionally, our comprehensive platform includes 500+ cancer cell lines, ensuring a wide selection for diverse research needs. Each well-characterized CDX model includes genetic profiles and growth curves, offering diverse research options. We provide subcutaneous, orthotopic, and experimental metastatic models, allowing researcher to select the best approach for their studies.

Click here to download the PDF version of our CDX animal models flyer.
Why Choose BioDuro for CDX Models?
At BioDuro, we offer an extensive cancer cell line bank to support a wide range of CDX mouse models. Each cell line is annotated with genetic profiles and detailed growth curves to help identify the best model for your research.
Our knowledgeable team provides personalized support and guidance, helping you select the cell lines that are most appropriate for your drug development goals. We use advanced technology in our state-of-the-art, AAALAC-accredited vivarium (>16,000m2) to deliver precise results for each CDX model.
Recognizing the unique nature of each cancer therapy, we offer fully customizable services tailored to your goals. Our seven global campuses adhere to stringent international standards, ensuring consistent quality, compliance, and operational excellence. As a trusted partner, we support drug development from discovery through to clinical trials and beyond, offering comprehensive solutions without geopolitical or intellectual property risks.
Applications of CDX Models in Drug Discovery
BioDuro’s CDX tumor models are used primarily in drug efficacy studies. By transferring tumor cell lines to mice, researchers can replicate the way human tumors behave in a living organism.

CDX models provide researchers with a powerful tool to evaluate tumor responses to potential therapies in vivo. They generate essential data on tumor growth inhibition, driving the development of advanced cancer treatments.


Our CDX models support a wide range of theapeutic approaches, including:

Small molecules

Peptides

Antibody-drug conjugates (ADCs)

Biologics

Caner typeModels
Bladder cancer5637, HT-1376, J82, RT-112/84, RT-4, T24
Blood cancerBC-3 sq, BC-3 sys, BJAB, CCRF-CEM, CCRF-SB, Dami, Daudi sq, Daudi sys, DL40, H9, H929, HEL9217 sq, HEL9217 sys, HL-60, HUT78, Jeko-1 sq, Jeko-1 sys, Jurkat, K562, Karpas-299 sq, Karpas-299 sys, Karpas422, Kasumi-1 sq, Kasumi-1 sys, KG-1, KMS11, L363, L428, L540, MEC-1, MEG-01, MINO, MM.1S, MM.1S, Molm13, Molm16, Molt-4, MV-4-11, Nalm6, NAMALWA, NB4, OCI-LY1, OCI-LY19, OCI-LY3 , OCI-LY7, P3HR-1, Raji, Ramos, REH sq, REH sys, RL sq, RL sys, RPIM8226, RS4;11, SKM-1, SU-DHL-10, SU-DHL-2, SU-DHL-5, THP-1 sq, THP-1 sys, TOLEDO sq, TOLEDO sys, U266 sq, U266 sys, U2932, U937, Z-138
Brain cancerBE(2)-C, BE(2)-M17, GOTO, IMR-32, NMC-G1, SH-SY5Y, SK-N-AS, SK-N-DZ, SK-N-FI, SK-N-SH, U251, U87MG
Breast cancerBT474, CAL51, Du4475, HCC1599, HCC1806, HCC1954, HCC1956, HCC38, HCC70, JIMT-1, MCF-7, MDA-MB-231, MDA-MB-361, MDA-MB-436, MDA-MB-453, MDA-MB-468, MX-1, ZR-75-1
Cervix cancerAN3CA, C-33-A, Ca-ski, HEC-1A, Hela, MES-SA/Dx5, SIHA
ChoriocarcinomaJEG-3, JAR
CholangiocarcinomaKKU-M213
Colorectal cancerATRFLOX, Caco-2, Colo-205, COLO-320 HSR, DLD-1, GP2D, HCT116, HCT116 IDH, HCT116 MTAP, HCT-15, HCT-8, HT-29 , HT-55, HuTu80, KM-12, LOVO, LS174T, LS513, NCI-H716, RKO, SNU-C1, SW1463, SW48, SW480, SW620, SW837, SW948, T84, WiDr
Esophageal cancerKYSE-410, KYSE-450, OE21
FibrosarcomaA204, A673, HT1080, MSTO-211H
Gastric cancerAGS, DLD-BRCA2, DLD-WT, HGC-27, Hs 746.T, MKN45, NCI-N87, NUCG-3, NUCG-4, OE19, SNU-1, SNU-16, SNU-601, SNU-719
Kidney cancer786-O, A-498, ACHN, Caki-1, OS-RC-2, RXF-393
Liver cancerC3A, Hep3B, HepG2, Huh1, HuH-6, Huh7, JHH-7, SK-Hep-1, SNU-398, SW13
Lung cancerA427, A549, A549DR, A549PR, Calu-1, Calu-3, Calu-6, DMS-114, DMS-53, DV90, EKVX, HCC4006, HCC827, LK-2, LU99, NCI-1373, NCI-H1155, NCI-H1299, NCI-H1437, NCI-H146, NCI-H1573-Luc, NCI-H1581, NCI-H1650, NCI-H1703, NCI-H1781, NCI-H1975, NCI-H1993, NCI-H209, NCI-H2110-Luc, NCI-H2122, NCI-H2170, NCI-H2171, NCI-H226, NCI-H2286, NCI-H23, NCI-H2807, NCI-H292, NCI-H3122, NCI-H322, NCI-H358, NCI-H441, NCI-H446, NCI-H460, NCI-H596, NCI-H69, NCI-H82, PC-9
MelanomaA101D, A2058, A375, HMCB, HT-144, Malme-3M, MDA-MB-435, MeWo, SK-MEL-28, SK-MEL-5, UACC257
Head and neck cancersFadu, KYM-1, Y79
Nasopharyngeal carcinomaC666.1
Ovarian cancerA2780, A2780-CIS, COC1, ES-2 , OVCAR-3, OVCAR-5, OVCAR-8 ADR, PA-1, SK-OV-3
Pancreatic cancerASPC-1, BXPC-3, Capan-1, CFPAC-1, HPAC, KP-2, KP-4, MIA PaCa-2, Panc02.03, Panc04.03, PANC-1, PSN-1, SU.86.86, SW1990
Prostate cancer22RV1, C4-2, DU-145, LNCaP-Clone-FGC, PC-3
Skin cancerA431
Thyroid cancerT.T
Syngeneic cell4T1, A20, B16F10, Colon26/C26, CT26, EMT6, GL261, H22, LL/2, MC38, PAN02, Renca, RM-1, S180
DR modelsBaf3-EGFR D770_N77insNPG, Baf3-EGFR D770_N77insSVD, Baf3-EGFR WT, Baf3-HER2 YVMA, Baf3-HER2WT

Remarks: sq = SubQ; sys = Systemic.


Fast and Efficient Research Solutions:

Easy and Rapid Selection with our online LOCUS Tumor Model Database

Quick Turnaround: Large capacity with 60+ dedicated scientists, ensuring no waiting queue and faster results

High signal-to-noise ratio, ensuring accurate and reproducible data


Contact Us:
If you’re exploring CDX models for your oncology research, our team is ready to assist. We’ll help you select the ideal model from our extensive library, offering personalized support throughout the drug discovery process.
Ready to get started? Unlock the full potential of CDX models with BioDuro. Contact us today to tailor solutions to your research needs.
Q&A on CDX Models
What are CDX models and why are they crucial to cancer research?
CDX models are essential for evaluating tumor responses to preclinical therapies. These in vivo models involve implanting human cancer cell lines into immunodeficient mice where they form tumors for study.
These models enable researchers to perform rapid screenings of prospective cancer therapies to identify possible treatments. CDX models are also very effective for conducting detailed efficacy studies to learn more about a drug’s potential before it reaches the market. CDX models for cancer research are available across a range of tumor types.
How do CDX models support drug development processes?
CDX models play a critical role in early-phase oncology testing. By simulating how drugs will perform against human tumors, these models help identify the most promising therapeutic candidates. BioDuro provides over 300 models spanning diverse cancer types, enabling tailored research solutions.
How do CDX models differ from PDX models?
CDX models are often compared to patient-derived xenograft (PDX) models. PDX models use tissues derived directly from human tumors, while CDX models use tissues derived from existing commercial cell lines.
CDX models are easily reproducible and grow quickly, making them ideal for high-volume drug efficacy testing with rapid timelines. However, they don’t have the complexity or heterogeneity of PDX models. Both options play an important role in oncological drug development. BioDuro offers both model types to suit your research needs.
How are BioDuro’s CDX models unique?
At BioDuro, we’re committed to offering an extensive range of CDX models with comprehensive tumor-type coverage. Our library supports a wide range of drug development needs, and our team is available to provide further guidance and personalized services throughout the entire process.
We rigorously validate each model to ensure accuracy, reliability, and reproducibility. We validate models with advanced imaging and analysis in our state-of-the-art, accredited labs. This ensures high-quality, reliable data for our clients every time.
How can BioDuro’s CDX models accelerate your research?
BioDuro’s CDX models are designed to streamline your oncology research process by delivering rapid, reliable, and actionable results. With advanced imaging technologies, extensive model coverage, and a proven track record in preclinical drug development, we help you reduce research timelines and identify promising therapeutic candidates efficiently. Backed by our global presence and integrated drug discovery platform, BioDuro accelerates your journey from discovery to breakthrough treatments.
Oncology
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