Small libraries
10 – 50mg of each compound
Purity - ≥90% (95% if desired) by HPLC/LC-MS for all compounds
1H-NMR for 5- 10% (or more, if required) of the compounds
Large libraries
10mg of each compound
Purity - ≥85% by (90% if desired) HPLC/LC-MS for all compounds
In general 1H-NMR for 5 - 10% of the compounds
Large collections of standard commercial building blocks (amines, acids, isocyanates, sulfonyl chlorides etc.)
Small libraries (20 - 500 compounds) to allow for rapid SAR exploration
Large libraries (1,000 - 10,000 compounds)
High-throughput or parallel medicinal chemistry for more complex chemistry
Track record of delivering ~88,000 compounds in the library space (small and large libraries)
Capacity to deliver 6,000 compounds/month
Multiple standard orbital shakers; Multiple shakers with heating/cooling capacity
Parallel inert atmosphere equipment
CEM Discovery Microwave with robot
Large shaking table for large libraries
15 x Parallel synthesizers for small libraries
6 x Purification using automated prep-HPLC and prep-TLC
8 x MPLCs/Combi-Flash
NMR: 11 sets,<1 hour turnaround time
LCMS: 66 sets,<1 hour turnaround time
HPLC: 30 sets,<1 hour turnaround time
Prep-HPLC: 44 sets,<24 hours turnaround time
SFC (Analytical): 8 sets,<24 hours turnaround time
SFC (Preparative): 8 sets,<24 hours turnaround time
Chiral-HPLC: 2 sets,<24 hours turnaround time
Prep-Chiral HPLC: 1 set,<24 hours turnaround time
Polarimeter: 4 sets,<1 hour turnaround time
GCMS: 3 sets,<1 hour turnaround time
DSC: 2 sets,<4 hours turnaround time
Depending on the project needs, we could adopt the packaging in barcoded vials/ARPs (Assay Ready Plates)
Automated system in place for ARPs in 384 wells formats, if required
Shipment to client in a desired format weekly or bi-weekly basis (or at a desired frequency)
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