CAR-T and CAR-NK Mouse Models
Overview of CAR-T and CAR-NK Mouse Models
CAR-T and CAR-NK therapies are innovative immuno-oncology treatments that harness the immune system to target and eliminate cancer cells. CAR-T therapy modifies T cells, equipping them with chimeric antigen receptors (CARs) to enhance their ability to recognize and destroy tumor cells. CAR-NK therapy operates similarly, leveraging natural killer cells for a broader immune response with reduced risks of severe side effects like cytokine release syndrome.
BioDuro’s CAR-T mouse models and CAR-NK models use NOG or equivalent mouse strains, combined with CDX or PDX systems to mimic human tumor growth. These models enable researchers to assess CAR-T efficacy, optimize therapeutic constructs, and address potential safety concerns. With extensive experience and a blend of in vivo and
in vitro assays in oncology research, we provide robust support for drug discovery efforts in
oncology.
Figure 1: In vitro assay results showing CAR-T cell activity and tumor response. Bar graphs (top) quantify immune response or tumor cell killing, while heat maps (bottom) display activity levels in multi-well assays.
Figure 2: Tumor regression curve (left) and in vivo bioluminescence imaging (right) demonstrating CAR-T efficacy in mouse models. Groups treated with CAR-T show significant reductions in tumor burden compared to the control group.
In vivo assays for CAR-T efficacy, as featured in Figures 1 and 2, provide detailed insights into tumor response and therapeutic impact.
Why Choose BioDuro for CAR-T and CAR-NK Mouse Models?
BioDuro offers a comprehensive solution for testing CAR-T and CAR-NK therapies:
Advanced Models: CAR-T and CAR-NK mouse models using immunodeficient strains and tumor systems (CDX and PDX).
Customization: Tailored studies aligned with your drug development goals, from CAR-T immunotherapy research to CAR-T efficacy optimization.
Global Expertise: Teams in AAALAC-accredited facilities offer advanced animal models uniquely integrated with complete DMPK services, ensuring ethical and accurate research.
Integrated Approach: Support across the entire drug development process, integrating CAR-T mouse models and CAR-NK models with broader immuno-oncology services for efficient timelines.
Our dedicated team ensures your therapies are tested with precision, helping you move closer to clinical success.
Applications of CAR-T and CAR-NK Mouse Models in Drug Discovery
CAR-T and CAR-NK mouse models are invaluable in evaluating cancer therapies during preclinical stages. Using human tumor cells (
CDX or
PDX models), these systems provide critical insights into the tumor microenvironment and therapy impact, including:
Efficacy Assessment: Measuring cancer cell elimination, tumor regression rates, and overall CAR-T efficacy.
Safety Evaluation: Identifying potential side effects such as toxicity or immune-related issues.
Therapy Optimization: Refining CAR-T immunotherapy and CAR-NK constructs to improve outcomes before advancing to clinical trials.
This data empowers pharmaceutical developers to address potential challenges early and improve the success rates of CAR-T and CAR-NK therapies in later stages.
Q&A
What are CAR-T and CAR-NK mouse models?
CAR-T and CAR-NK mouse models are advanced preclinical systems used to evaluate the efficacy of CAR-T immunotherapy and CAR-NK therapies. These models use CDX or PDX tumor systems within immunodeficient mice, mimicking human immune responses to test how effectively the therapies target and destroy cancer cells. Examples include colorectal, lung, and breast cancer CDX models, as well as PDX models characterized for genomic and pharmacological relevance.
How do CAR-T and CAR-NK models advance cancer research?
These models enable researchers to study therapy efficacy, tumor response, and potential side effects in a controlled environment, providing crucial insights that guide clinical trial preparation.
What makes BioDuro’s CAR-T and CAR-NK models unique?
Our models are supported by extensive experience in immuno-oncology, leveraging NOG strains and advanced genetic engineering to replicate human immune responses accurately. We offer flexible study designs and integration with comprehensive oncology research services.
How are CAR-Ts and CAR-NKs used in immunotherapy?
CAR-T and CAR-NK therapies are engineered to identify and kill cancer cells by targeting specific antigens. CAR-T focuses on modifying T cells, while CAR-NK therapy uses NK cells for a broader immune response. BioDuro uses specialized mouse models to evaluate these therapies' performance and safety, ensuring thorough validation before clinical trials.
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