Overview of Orthotopic Models
Orthotopic models are a widely used preclinical cancer research tool for testing prospective therapeutic agents. In an orthotopic model, tumor cells or tissues are implanted into the same anatomical site in mice or other small animals where they originated in the body. Over time, these cells grow and develop into a tumor, closely mimicking the natural environment of cancer.
By using site-specific tumor implantation, these studies preserve the tumor microenvironment, providing realistic and accurate insights into tumor behavior and treatment efficacy. All tumors are monitored in vivo using bioluminescence imaging (BLI) for precise tracking.
| Orthotopic CDX | Inoculation |
| A549-Luc | Lung |
| ACHN-Luc | Kidney |
| BC3-Luc | IP |
| BXPC-3-Luc | Pancreas |
| Capan-1-Luc | Pancreas |
| CCRF-CEM-Luc | IV |
| Daudi-Luc | IV |
| HepG2-Luc | Liver |
| HL-60-Luc | IV |
| Huh-7-Luc | Liver |
| Jeko-1-Luc | IV |
| Jurkat-Luc | IV |
| K562-Luc | IV |
| Karpas-299-Luc | IV |
| L363-Luc | IV |
| MM1S-Luc | IV |
| Molm-13-Luc | IV |
| MV-4-11-Luc | IV |
| Nalm6-Luc | IV |
| Raji-Luc | IV |
| THP-1-Luc | IV |
| U87MG-Luc | Brain |
U87-MG-Luc: Our U87-MG-Luc glioblastoma orthotopic model, combined with bioluminescence imaging (BLI), enables precise tracking of tumor progression and therapeutic efficacy. This advanced model is part of our extensive suite of preclinical tools for oncology research.
Figure 1: U87-MG-Luc glioblastoma orthotopic model results. The top graph shows tumor progression (total flux) over time, while the bottom graph monitors body weight changes across treatment groups. Bioluminescence imaging (right) visualizes tumor burden in each group, demonstrating therapeutic efficacy and compound impact.
Why Choose BioDuro for Orthotopic Mouse Models?
At BioDuro, we provide a comprehensive range of orthotopic models as part of our integrated oncology research services. Our genetically engineered mouse models are tailored for various cancer types, including brain, liver, pancreas, skin, and lung cancer.
Our advanced orthotopic models include luciferase-labeled CDX lines for detailed tumor tracking and drug efficacy analysis. All studies are conducted in our AAALAC-accredited facilities, which adhere to stringent safety and ethical standards, and are equipped for large-scale pharmaceutical research.
BioDuro’s integrated approach to drug development accelerates timelines from discovery through clinical testing and manufacturing. Our team of expert scientists provides personalized support, helping you select the most appropriate orthotopic models and customize studies to meet your specific research goals.
Applications of Orthotopic Tumor Models in Oncology
BioDuro uses orthotopic models to gain insights into various cancers and their response to new therapies. These models replicate the tumor's original microenvironment, offering valuable data on drug interaction, tumor response, and safety profiles.
During the study, tumors are monitored for changes in size, structure, and drug sensitivity using advanced imaging techniques. This information helps researchers understand how therapies interact with tumors and assess their safety and efficacy before advancing to clinical trials.
Contact Us
Our extensive range of orthotopic models can be tailored to meet your research needs, including tracking tumor response and testing therapeutic efficacy.
Contact us today to schedule a consultation and explore our
oncology research services.
Q&A on Orthotopic Models
What are orthotopic models and why are they important in cancer research?
Orthotopic models involve implanting cancer cells or tissues into immunocompromised mice at their original location in the body. These models closely mimic the conditions of human cancers, enabling researchers to assess drug efficacy and study natural tumor growth and metastasis.
How do orthotopic models compare to other tumor models?
Unlike subcutaneous models that implant tumors under the skin, orthotopic models place tumors in their organ of origin. This accurately replicates tumor interactions with surrounding tissues and metastatic patterns.
What types of cancer research use orthotopic models at BioDuro?
BioDuro uses orthotopic models for a variety of cancer types, including pancreatic, liver, and lung cancers. These models provide realistic insights into tumor progression, drug response, and metastatic behavior, enabling researchers to evaluate the efficacy and safety of new therapies.
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