Overview of Humanized Mouse Models
At BioDuro, we use humanized mouse models for immuno-oncology research and drug development. These advanced models are created by modifying mice with human cells, tissues, or genes to closely replicate the human immune system functions and disease processes. This enhances the translational value of preclinical studies by providing a more accurate platform for evaluating potential therapies.
We offer two categories of humanized mouse models:
PBMC Models: Utilizing peripheral blood mononuclear cells, NOG proteins, or equivalent strains to observe immune responses. These models enable the reconstitution of human immune systems, providing critical insights for evaluating BiTE and immunomodulatory reagents.
Genetically-Modified Models: Incorporating human genes into the mouse genome to study immune system behavior and therapeutic efficacy, particularly in T-cell-focused treatments. These models are validated with robust pharmacological data, ensuring high reliability.
Our humanized mouse models allow researchers to accurately assess immune system responses, evaluating the efficacy of immunotherapies, and address safety concerns before advancing to clinical trials.
Why Choose BioDuro for Humanized Mouse Models?
We combine world-class expertise and cutting-edge technology to deliver reliable and customizable humanized mouse model services. Here’s why researchers choose us:
Expert Team: Our global team of oncology and immunotherapy specialists has extensive experience in pharmaceutical discovery and development.
Advanced Technology: We use state-of-the-art facilities, including AAALAC-accredited animal facilities with uniquely integrated biology and DMPK services, to support large-scale, complex studies with robust immune system reconstitution.
Customization: Flexible model options tailored to meet your research objectives, including studies of checkpoint inhibitors, CAR-T cell therapies, and more.
Integrated Approach: From discovery to clinical trials and manufacturing, our integrated drug discovery and development platform ensures efficiency without compromising quality or accuracy.
Global Presence: We’re equipped to scale your research seamlessly while adhering to the highest safety and ethical standards.
LOCUS Querying Database: Quickly identify oncology models based on cancer type, growth kinetics, pharmacology, or genomics for precise study alignment.
Applications of Humanized Mouse Models in Oncology
Humanized mouse models are critical for evaluating the safety and efficacy of oncology therapies under development. By mimicking human biological conditions in immunodeficient mice, these models provide a robust platform to:
Assess how oncological immunotherapies will perform in the human body.
Address safety and efficacy concerns before clinical trials.
Develop personalized therapies for complex or rare cancers that lack effective treatment options.
Our humanized mouse models—validated through rigorous pharmacological testing—are especially valuable for advancing research in immunotherapy and personalized medicine, improving clinical trial success rates.
Contact Us
Ready to advance your research with cutting-edge humanized mouse models? BioDuro’s expert team is here to help.
Contact us today to discover how our models can accelerate your oncology breakthroughs.
Q&A on Humanized Models in Oncology Drug R&D
What are humanized mouse models and how are they used in oncology research?
Humanized mouse models are laboratory mice modified with human stem cells, tissues, or genes to simulate human immune system responses. In oncology research, these models are essential for studying human-specific antigens, immune responses, and the efficacy of new immunotherapies in a controlled environment.
How do humanized mouse models improve the outcomes of immunotherapy studies?
By replicating the conditions of a human immune system, humanized mouse models provide precise insights into how cancer therapies interact with immune cells. This accuracy enables researchers to optimize therapies and improve clinical trial outcomes, reducing the risk of failure during development.
What makes BioDuro’s humanized models unique in the industry?
Our models combine genetic fidelity with robust immune system reconstitution for reliable, accurate results. Supported by AAALAC-accredited facilities and advanced technologies like the LOCUS Querying Database, BioDuro’s integrated drug development platform ensures tailored solutions that meet your specific objectives.
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