Overview of PDX Models
Patient-derived xenograft (PDX) models are critical tools in cancer research, enabling scientists to observe how human tumors behave in biological systems. These models involve grafting human tumor tissues into immunocompromised mice to study drug efficacy for potential cancer therapies. By closely mimicking human tumor growth, PDX models provide highly accurate data for drug development.
In a PDX model, human tumor grafts are transferred to immunocompromised mice, which are then used to study drug efficiency for prospective cancer therapies. PDX models are so effective because they are able to replicate human tumor growth very precisely, making for accurate results to aid in drug development.
BioDuro offers approximately 90 validated PDX models focused on gastric, lung, and colorectal cancers, providing a unique portfolio for efficacy studies.
| Cancer Type | PDX Model # |
| Colorectal | 28 |
| Esophagus | 6 |
| Gallbladder | 3 |
| Head&Neck | 1 |
| Kidney | 5 |
| Liver | 3 |
| Lung | 27 |
| Ovarian | 2 |
| Pancreas | 1 |
| Sarcoma | 2 |
| Stomach | 27 |
| Total | 105 |
Why Choose BioDuro for PDX Models
At BioDuro, we combine cutting-edge oncology research with a comprehensive approach to drug development, offering:
Extensive Options: Over 90 PDX models, covering common cancers (lung, colorectal, stomach) and rare types (gallbladder, sarcoma, pancreatic).
Advanced Genomic Characterization: Ensures data accuracy and reliability.
Expertise: A team of skilled researchers providing tailored recommendations based on pharmaceutical goals.
State-of-the-Art Facilities: AAALAC-accredited vivariums equipped with advanced research technology.
Seamless Integration: PDX models integrate with CDX models, immuno-oncology assays, and CAR-T platforms for a streamlined research process.
Efficiency: Rapid study initiation, frequent updates, and short turnaround times.
Our models support diverse studies, including small molecules, antibodies, ADCs, and combination therapies.
Applications of PDX Models in Oncology
PDX models play a transformative role in oncology, supporting critical stages of the drug development process. By preserving the complexity and heterogeneity of human tumors, PDX models allow researchers to accurately evaluate drug efficacy and resistance in pharmaceutical candidates. These studies shed light on how potential therapies interact with cancer cells in a tumor microenvironment, offering invaluable data for advancing treatment strategies.
Beyond efficacy testing, PDX models are a key tool for biomarker discovery, driving earlier and more precise cancer diagnoses and guiding the development of targeted therapies. Its ability to retain patient-specific tumor traits makes it especially effective for identifying novel biomarkers that inform therapeutic breakthroughs.
PDX models also facilitate the design of combination therapies, which are crucial for addressing biological resistance mechanisms in cancer treatment. These applications help improve clinical outcomes by enhancing the effectiveness of therapies and overcoming common barriers in existing treatment regimens.
Contact Us
BioDuro is your partner for developing innovative
oncology therapies. With world-class facilities, advanced technology, and a dedicated team, we support you at every stage of drug development.
Learn more about our PDX models and oncology research solutions by
contacting us today.
Q&A
What are PDX models and how are they used in oncology?
Patient-derived xenograft (PDX) models involve transplanting tumor tissue directly from patients into immunocompromised mice. These models are central to PDX and oncology research, as they retain the biological complexity of the original tumor, providing a preclinical platform to study tumor behavior and assess potential cancer therapies in a living system.
How do PDX models compare to traditional xenograft models?
Unlike traditional xenograft models, which use tumors derived from established cell lines, PDX models preserve the heterogeneity of patient-derived tumors. This enables more accurate predictions of clinical outcomes and improves the reliability of drug development studies.
What cancer types are available in BioDuro’s PDX library?
We offer a robust library of over 90 PDX models spanning a variety of cancer types, including:
Colorectal, lung, and stomach cancers
Rare cancers such as pancreatic, gallbladder, and sarcoma
How does BioDuro ensure the quality of its PDX models?
We employ stringent quality control measures to maintain the integrity and reliability of its models:
Genomic profiling: Confirms each model’s consistency with the original tumor.
Pharmacological validation: Ensures reproducible drug response data.
Continuous development: Expands the library based on emerging research needs.
Compliance with AAALAC standards: Guarantees adherence to ethical and scientific rigor.
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