2,000 fragments: 50% internally synthesized
Ro3 compliant drug lead-like fragments
240 NP-like fragments
Free from known structural alerts
100 ≤ MW < 300
0 < ClogP ≤ 2.75
Purity ≥ 95% (metal ion free)
Aqueous solubility ≥ 1 mM; DMSO solubility ≥ 100 mM (room temperature)
HBD ≤ 3
HBA ≤ 6
Nrot ≤ 4
20 ≤ TPSA ≤ 90
Robust with wide dynamic range (Kd: nM – mM)
Quantitative binding info: kon, koff, Kd
Binding stoichiometry
Very low protein consumption
High-throughput (Biacore 8K)
Parallel setup, 8 channels, 2 cells/channel
Ideal for fragment based screening (FBS) and rapid follow-ups with dose-response confirmation of fragment hits
oIdeal for supporting fragment optimization and evolution with Kd and binding kinetics
Our customized fragment library of 2,300 compounds includes nearly 50% internally synthesized that are not covered by commercial fragments, which provides differentiated value and enhances the probability of identifying truly novel hits
Chemical structures of fragment hits are disclosed to clients who are offered full freedom to operate
Transparent cost structure, no downstream financial obligations
Deep expertise in SPR and in the entire process of FBDD
Home
