April 17, 2025 (11:00am ET)
Fuelled by the global surge in type 2 diabetes and obesity, the GLP-1 market is set to explode from $20 billion in 2024 to $50 billion by 2030, offering vast opportunities for innovation. This webinar provides a deep dive into the latest advancements and best practices in GLP-1 drug development, covering the journey from early discovery synthesis, biology modelling to in-vitro and in vivo testing, and fostering a vibrant exchange of insights between academia and industry.
We'll also explore the shift from daily-multiple to once-weekly dosing, innovations in extended dosing regimens and dual/triple agonisms, and the potential of oral formulations. Join us to uncover interdisciplinary strategies in Biology, Chemistry, and DMPK that are shaping the future of GLP-1 drug development, highlighted through real-world case studies.
What you will discover:
The evolution of GLP-1 therapies: Emphasizing the transition from daily-multiple injections to once-weekly injections, significantly boosting patient compliance.
The Trajectory of GLP-1 Drug Development: Discussing advancements such as longer circulation, innovations in dual/triple agonisms, new indication explorations, and the potential of oral formulations.
In-vitro Assays: Development of in-vitro assays specifically designed for the bioanalysis of GLP-1 agonists and antagonists.
Disease Models: Exploration of NASH/MASH, Diabetes, and Diet-Induced Obesity (DIO) models.
Synthesis Strategies: Comparative insights into Solid Phase Synthesis and Liquid Phase Synthesis for GLP-1R.
Synthetic and Testing Differences: Insights into peptide vs. small-molecule GLP-1R agonists in both synthesis and testing fields.
ADME and PK of Polypeptides: comprehensive analysis of in vitro ADME properties and in vivo pharmacokinetic profiles.
Real-World Case Studies: discover best practices in Biology, Chemistry, and DMPK fields.
Speakers:
Associate Professor
Beijing University of Chinese Medicine
Director of Chemistry
BioDuro
Lead of Discovery Biology (Jiangsu Site)
BioDuro
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