Ex Vivo Three-dimensional Tumor Growth Assay: 3DX-TGA
Praveen Nair#, Dileep Nair#, Kaede Hinata#, Cyrus Mirsaidi, Junjie Wu, Yong Hu, Brett Hall#
# Molecular Response LLC
Poster on the establishment, serial propagation and molecular characterization of 300+ ex vivo 3D (3DX) models spanning 16 tumor indications, as a practical alternative to PDX models. Presented by Brett Hall, Ph. D., at AACR 2017.
hTME-3DX Screen and Verify™ is based on the proprietary primary tumor bank and 3D drug screening platform that was developed by Molecular Response, through a large body of academic and commercial research over the past decade, as well as, internal expertise in ex vivo cell cultures and human tumor sample preservation.
Novel Gastro-Retentive Formulation for Methyldopa Using Hot Melt Extrusion (HME) Technology
Ruchit Trivedi, David Zama, Mark Previti, and J. Blair West
Poster on formulation of a novel gastro-retentive sustained release oral formulation for methyldopa to treat Type I diabetes, presented by Ruchit Trivedi, Ph. D., at AAPS 2016.
Reducing Residual Crystallinity in Hot Melt Extrusion (HME) Formulations Optimization
David Zama and J. Blair West
Poster on improvement of existing hot melt extrusion formulations showing recrystallization due to moisture absorption, and high percentage impurities, presented at AAPS 2016.