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Fact Sheets

Scale-up Chemistry

Developing robust and cost-effective chemistry processes from early discovery to kilogram quantity process chemistry.

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DMPK

Providing world-class quality data for in vitro ADME and in vivo PK studies.

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Oncology

Preclinical solutions for anti-cancer drug discovery in 2D and 3D cellular models, and animal tumor models.

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hTME-3DX Screen and Verify™

The first drug screening platform to combine humanized 3D cell culture and patient-derived xenograft models.

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Analytical Development

Providing necessary data for the development process from discovery candidates to clinical trial materials.

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Manufacturing

cGMP manufacturing services with quality, efficiency, and timeliness of delivery in mind.

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Amorphous Dispersions

Bioavailability enhancement solutions for poorly soluble compounds.

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Scientific Posters

Ex Vivo Three-dimensional Tumor Growth Assay: 3DX-TGA

Praveen Nair#, Dileep Nair#, Kaede Hinata#, Cyrus Mirsaidi, Junjie Wu, Yong Hu, Brett Hall#

# Molecular Response LLC

Poster on the establishment, serial propagation and molecular characterization of 300+ ex vivo 3D (3DX) models spanning 16 tumor indications, as a practical alternative to PDX models. Presented by Brett Hall, Ph. D.,  at AACR 2017. 

hTME-3DX Screen and Verify™ is based on the proprietary primary tumor bank and 3D drug screening platform that was developed by Molecular Response, through a large body of academic and commercial research over the past decade, as well as, internal expertise in ex vivo cell cultures and human tumor sample preservation.

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Novel Gastro-Retentive Formulation for Methyldopa Using Hot Melt Extrusion (HME) Technology

Ruchit Trivedi, David Zama, Mark Previti, and J. Blair West

Poster on formulation of a novel gastro-retentive sustained release oral formulation for methyldopa to treat Type I diabetes, presented by Ruchit Trivedi, Ph. D.,  at AAPS 2016. 

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Reducing Residual Crystallinity in Hot Melt Extrusion (HME) Formulations Optimization

David Zama and J. Blair West

Poster on improvement of existing hot melt extrusion formulations showing recrystallization due to moisture absorption, and high percentage impurities, presented at AAPS 2016.

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