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BioDuro’s pharmacology team has extensive drug discovery and development experience in the pharmaceutical industry enabling us to support fully integrated programs, including study design and data interpretation. Special expertise in metabolic and inﬂammatory diseases is coupled with a commitment to working with clients to develop customized models for rare diseases. By working together closely, our chemists, discovery biologists, and drug metabolism and pharmacokinetics (DMPK) scientists are able to provide BioDuro clients a range of flexible service models including integrated programs, full time employee (FTE) services or fee-for-services (FFS).
BioDuro’s pharmacology team has developed highly clinically translatable animal NASH model to evaluate drug candidates. With short NASH induction periods of 6 weeks in mice and 8 – 12 weeks in hamsters our NASH models successfully mimics the pathogenesis of clinical NASH patients and exhibits hallmarks of NASH, including steatosis, lobular inflammation, ballooning and fibrosis within 20 weeks of dieting.