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Reducing Residual Crystallinity in Hot Melt Extrusion (HME) Formulations Optimization

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Reducing Residual Crystallinity in Hot Melt Extrusion (HME) Formulations Optimization

By screening a variety of additives, a hot melt extrusion formulation which used to recrystallize significantly due to moisture absorption was improved. The resulting formulations remained amorphous even at high humidity environment with low degradation impurities.

David Zama and J. Blair West

Poster on improvement of existing hot melt extrusion formulations showing recrystallization due to moisture absorption and high percentage impurities, presented at AAPS 2016.