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Orthotopic Tumor Models Data Sheet

Providing clinically relevant models for your novel cancer drugs

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Orthotopic Tumor Models

Orthotopic models are models with tumor cell lines seeded into their natural locations. Orthotopic implantation establishes a more realistic tumor microenvironment for a higher degree of confidence in clinical efficacy. The tumor microenvironment has been shown to influence tumor development and response to anticancer therapies. In response to the need for clinically relevant in vivo tumor models, BioDuro has developed orthotopic models for the following tissue types:

  • Liver
  • Lung
  • Breast
  • Colon
  • Prostate
  • Leukemia
  • Cervix
  • Brain
  • Melanoma

Efficacy Evaluation

Tumor Development and Therapeutic Reponse

  • Clinical signs
  • Survival study
  • Bioluminescence imaging (BLI) with luciferase-labeled cell lines

Orthotopic Tumor Models Efficacy Evaluation for Bioluminescence imaging (BLI) with luciferase-labeled cell lines

Luciferase Gene Labeled Cancer Cell Lines and Orthotopic Models

Cancer TypeCancer Cell LineSpeciesValidated Growth Curve
Liver Cancer
HepG2-Luc
Hep3B-Luc
HUH-7-Luc
MHCC97H-Luc
MHCC97L-Luc
Human
Human
Human
Human
Human

 

Yes
Yes
Ongoing
Yes
Ongoing
Lung Cancer
P53-RE-Luc/A549
A549-Luc
Human

 

Yes
Yes (intracranial metastases)
Breast Cancer
MDA-MB-231-Luc
MCF-7-Luc
Human
Human

 

Ongoing
Ongoing
Colorectal Cancer
HT-29-Luc
SW480-GFP-Luc
CT-26-Luc
Human
Human
Mouse

 

Yes
Yes (liver metastases)
Ongoing
Prostate Cancer
PC-3-M-Luc
22RV1-Luc
Human
Human

 

Yes
Yes
Leukemia & Lymphoma
K562-Luc-GFP
Raji-Luc
HL60
MV-4-11
Human
Human
Human
Human

 

Ongoing
Yes
Yes
Yes
Cervical CancerHela-LucHuman

 

Yes
GlioblastomaU87MGHuman

 

Yes
Melanoma
A375-Luc
B16-F10-Luc
Human
Mouse

 

Yes (intracranial metastases)
Ongoing