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Webinar Series

Advances in Drug Discovery from
Hit to Candidate Webinar

• Next Gen Computational & AI Approaches
• Small Molecules, Big Advances: Early to Late Lead Op
• Modern Biologics: Antibodies & Cell Therapies
• Advanced Preclinical & Translational Animal Models

Join us at this virtual conference to learn about new insights and advances that are accelerating drug discovery—from hit to candidate—for small molecules and biologics. Promising hits often have development challenges that require innovative solutions to reach the key milestone of declaring a candidate.

 

The live webinar format will have one speaker per week, followed by an interactive Q&A session with a global audience.

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Upcoming Events

April 28th

9:00am PDT

Dr. Nicholas A. Meanwell,

Vice President, Head Discovery Chemistry Platforms Department of Small Molecule Drug Discovery, Bristol Myers Squibb
The Discovery of the HIV-1 Attachment Inhibitor Fostemsavir

May 5th

9:00am PDT

Dr. Ian Storer,

Director of Medicinal Chemistry at AstraZeneca
Fragment screening as an adaptable approach for hit-to-lead generation in medicinal chemistry

 

FULL AGENDA

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Next Gen Computational & AI Approaches Small Molecules, Big Advances: Early to Late Lead Op Modern Biologics: Antibodies & Cell Therapies Advanced Preclinical & Translational Animal Models
Modeling approaches and in silico systems used to shorten discovery timelines and reduce cost Modern technologies and synthetic methodologies to accelerate the H2L and LO phases of drug discovery Includes the growing impact of biologics, current challenges and innovative technologies Innovative approaches to better assess PK, efficacy and safety closer to clinical settings

Dr. Apurba K Bhattacharjee, Georgetown University Medical Center, Georgetown University(More Info)
Pharmacophore modeling for potential drug discovery – October 14th, 2020
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Q&A

Dr. Evan Feinberg, Genesis Therapeutics(More Info)
Unifying AI and biotech to accelerate and optimize drug discovery & development – November 11th, 2020

Dr. Zachary Sun, Tierra Biosciences(More Info)
Cell-free synthetic biology for high-throughput, custom protein production -December 16th, 2020

Dr. Ana Cristina Puhl Rubio,  Collaborations Pharmaceuticals(More Info)
COVID-19 Drug Discovery at Collaborations Pharmaceuticals – March 3rd, 2021
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Q&A

Dr. Kaushik Chakravarty,  VeriSIM Life(More Info)
Redefining preclinical and clinical drug development to advance human health – March 31st, 2021

Dr. Spandan Chennamadhavuni, Emory University(More Info)
Novel Macrocyclic Drugs for cancer Treatment – Exploring “beyond rule-of-five (bRo5)” chemical space – October 21st, 2020
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Q&A

Dr. Justin Hall, Pfizer Pharmaceuticals(More Info)
A simple model for determining ligand affinity from irreversible thermal shifts – October 28st, 2020
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Dr. Lewis D. Pennington, Alkermes(More Info)
Leveraging the Necessary Nitrogen Atom for Multiparameter Optimization in Chemical Biology and Drug Discovery – Nov 18th, 2020
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Q&A

Dr. Surya K. De, Supra Sciences(More Info)
Drug Discovery Hit to Lead – Inhibitors of PI-3K/AKT/mTOR Pathway – January 13th, 2021
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Dr. Vincent Jacques, DeuteRx, LLC(More Info)
Deuterium in drug discovery and development – February 10th, 2021
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Dr. Apurba Dutta, University of Kansas(More Info)
Cytotoxic Marine Natural Product Jaspine B: A Medicinal Chemical Investigation – April 14th, 2021
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Dr. Nicholas A. Meanwell, Bristol Myers Squibb(More Info)
The Discovery of the HIV-1 Attachment Inhibitor Fostemsavir – April 28th, 2021

Dr. Bing Xia, GlaxoSmithKline(More Info)
DEL-Enabled Discovery of Novel MoA and Structurally Unique IDO1 Inhibitors – April 21st

Dr. Ian Storer, AstraZeneca(More Info)
Fragment screening as an adaptable approach for hit-to-lead generation in medicinal chemistry – May 5th, 2021

Dr. Lore Gruenbaum, The Leukemia & Lymphoma Society (More Info)
Antibody and Cell Therapies in blood cancer: successes & challenges – December 2nd, 2020
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Dr. Haizhen Liu, BioAtla(More Info)
Novel Conditional Active Bispecific T Cell Engagers Targeting Solid Tumors – January 20th, 2021

Dr. Uriel Moreno, Stanford University(More Info)
Plasticity of Human Natural Killer Cells in the Tumor Microenvironment -March 17th, 2021
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Dr. Jeffrey Leyton, Université de Sherbrooke (More Info)
Journey to the Center of the Cell: Reprogramming Intracellular Transport to the Nucleus Enhances Tumor Killing for Antibodies Conjugated to Nuclear-Active Payloads – February 24th, 2021
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Dr. Yurong Lai , Gilead Sciences(More Info)
Model informed compound selection in drug discovery: The Why and How – November 4th, 2020
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Q&A

Dr. Kin-Hoe Chow, Dana Farber Institute(More Info)
Creation of patient derived cancer models at scale leverages patient diversity for improved clinical trials predictions – December 9th, 2020


Accelerated Development: Fast path to the clinic Discovery & preclinical approaches that enable rapid development

Dr. Daniel Treffer, Melt Prep (More Info)
Rapid and lossless prototyping of HME formulations in the milligram to gram scale via Vacuum Compression Molding – June 30th
View recording
Q&A

Dr. Chad Brown, Merck (More Info)
Hot Melt Extrusion as a Key Enabler of Developing Products of Low Solubility Compounds – June 2nd
Q&A

Dr. Xiaohu Deng, Viracta (More Info)
Phase-appropriate CMC Strategies in Drug Product Development – July 14th
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Q&A

Chandra Kelley, Pfanstiehl (More Info)
Key Considerations in Accelerating Biopharma Formulation Development – August 11th

Seth Forster, Merck (More Info)
Long-Acting Implants: Design for Durable Drug Delivery – August 4th

Dr. John Shelley, Schrodinger (More Info)
Formulation Development for Small Molecules and Biologics Enhancements with Molecular Modeling – July 28th
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Dr. Andrea Browning, Schrodinger (More Info)
Formulation Development for Small Molecules and Biologics Enhancements with Molecular Modeling – July 28th
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Dr. Raimar Löbenberg, University of Alberta (More Info)
Presentation title coming soon – Date TBD
Enhanced Bioavailability Approaches that enhance solubility of challenging API to enable clinically viable formulations

Dr. Harsh Chauhan, Creighton University (More Info)
Formulation Considerations for development of Ternary Solid Dispersions – June 23rd
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Dr. Dedong Wu, Astrazeneca (More Info)
Improving Bioavailability by Prodrug Approach – September 1st

Dr. Feng Zhang, UT Austin (More Info)
Hot-melt extrusion to prepare amorphous solid dispersions: key concepts and common misperceptions – July 7th
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Q&A

Dr. Mo Maniruzzaman, UT Austin (More Info)
3D printing and state-of-the-art manufacturing techniques to advance drug delivery – Date TBD

Dr. Yi-Ling Hsieh, AbbVie (More Info)
Lipid-Based Formulation – The Impact on Biopharmaceutics and Patient Centricity – July 21st
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Dr. Abu Serajuddin, St. John’s University (More Info)
Development of HPMCAS-based amorphous solid dispersions by melt extrusion 21st – Date TBD
Continuous Processing Topics covered will include uses of technologies such as: amorphous solid dispersion, continuous granulation, coating and extrusion

Dr. Michael Thompson, McMaster University (More Info)
Developments in Twin-Screw Granulation – May 26th View recording
Q&A

Andy Birkmire, GEA (More Info)
Successful Strategies for Developing a Continuous Manufacturing Process – June 9thView recording Q&A

Jim Marjeram, O’Hara (More Info)
Advantages of Continuous Tablet Coating – September 8th
Oral Delivery Innovative approaches to address oral delivery of biologics, including: proteins, peptides, nucleic acids, and beyond

Dr. John Vrettos, Enteris BioPharma (More Info)
Breaking Through the Barriers of Oral Biologics – June 16thView recording
Q&A

Dr. Stephen Hoag, University of Maryland (More Info)
Presentation title coming soon – Date TBD


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