Bioduro

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Drug Discovery at BioDuro (Icon)

DMPK

High quality in vitro and in vivo studies to help prediction of therapeutic outcomes. Integration with early formulation development studies that enable more accurate scaling of results to humans.

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Overview

BioDuro provides insightful Drug Metabolism and Pharmacokinetic services through its unique position as a drug discovery and development organization. With strong credentials and experience in chemistry, biology, pharmacology, and formulation development, the DMPK team performs studies with a wide variety of animal models in an AAALAC accredited and GLP-like environment.

BioDuro Advantage

  • Integration with drug discovery and drug development teams
  • 5-10 day project turnaround time
  • Custom studies for ADME
  • AAALAC accredited animal facilities
  • GLP-like laboratory environment
  • Dedication to animal welfare

Services

  • In vitro ADME
    • Physicochemical properties
    • In vitro drug metabolism
    • Permeability measurement
    • Drug-Drug Interaction
  • In vivo PK
    • Metabolite identification and quantification
    • Tissue distribution studies
    • Metabolite identification and quantification
    • Formulation development
    • In-life dosing and sampling
    • Bioanalytical method development
    • Bioanalysis

Capabilities

  • PO, IV, SC, IP, IN; IV/PO cassette dosing
  • Multiple dosage routes
  • Multiple cannulation models
  • Liver microsome/hepatocyte stability
  • CYP phenotyping
  • Metabolite ID (phase I and II)
  • Caco-2
  • PAMPA
  • CYP inhibition assay
  • Time dependent inhibition
  • GSH trapping assay
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