Overview

BioDuro provides insightful Drug Metabolism and Pharmacokinetic services through its unique position as a drug discovery and development organization. With strong credentials and experience in chemistry, biology, pharmacology, and formulation development, the DMPK team performs studies with a wide variety of animal models in an AAALAC accredited and GLP-like environment.

BioDuro Advantage

• Integration with drug discovery and drug development teams
• 5-10 day project turnaround time
• Custom studies for ADME
• AAALAC accredited animal facilities
• GLP-like laboratory environment
• Dedication to animal welfare

Services

• In vitro ADME
  • Physicochemical properties
  • In vitro drug metabolism
  • Permeability measurement
  • Drug-Drug Interaction
• In vivo PK
  • Metabolite identification and quantification
  • Tissue distribution studies
  • Metabolite identification and quantification
  • Formulation development
  • In-life dosing and sampling
  • Bioanalytical method development
  • Bioanalysis

Capabilities

• PO, IV, SC, IP, IN; IV/PO cassette dosing
• Multiple dosage routes
• Multiple cannulation models
• Liver microsome/hepatocyte stability
• CYP phenotyping
• Metabolite ID (phase I and II)
• Caco-2
• PAMPA
• CYP inhibition assay
• Time dependent inhibition
• GSH trapping assay