Overview

BioDuro provides insightful Drug Metabolism and Pharmacokinetic services through its unique position as a drug discovery and development organization. With strong credentials and experience in chemistry, biology, pharmacology, and formulation development, the DMPK team performs studies with a wide variety of animal models in an AAALAC accredited and GLP-like environment.

BioDuro Advantage

• Integration with drug discovery and drug development teams
• 5-10 day project turnaround time
• Custom studies for ADME
• AAALAC accredited animal facilities
• GLP-like laboratory environment
• Dedication to animal welfare

Services

• In vitro ADME
  • Physicochemical properties
    • Kinetic, thermodynamic stability
    • LogP, LogD
  • In vitro drug metabolism
    • Hepatocyte stability assay 
    • Microsomal stability assay
    • Plasma stability assay
  • Permeability measurement
    • Caco-2
    • PAMPA
    • MDR1-MDCK (new offering)
  • Drug-drug interaction
    • Cytochrome P450 time dependent inhibition assay (single-point or IC50 shift)
    • Cytochrome P450 inhibition assay (DDI)
• In vivo PK
  • Metabolite identification and quantification
  • Tissue distribution studies
  • Formulation development
  • In-life dosing and sampling
  • Bioanalytical method development
  • Bioanalysis

Capabilities

• PO, IV, SC, IP, IN; IV/PO cassette dosing
• Multiple dosage routes
• Multiple cannulation models
• Liver microsome/hepatocyte stability
• CYP phenotyping
• Metabolite ID
• Caco-2
• PAMPA
• CYP inhibition assay
• Time dependent inhibition
• GSH trapping assay

Equipment

• LC-MS/MS
  • API-6500+
  • API-5500
  • API-4000 QTRAP
  • API 4500 QTRAP
  • API 4000
• UPLC/HPLC
  • Shimadzu LC-30AD
  • Waters H-Class
  • LC-20AD