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Drug Discovery at BioDuro (Icon)

Chemistry

Drug discovery through advanced chemistry. Enhancing projects with cutting edge expertise in medicinal, synthetic, and computational chemistry.

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Overview

With an established reputation as one of the most reliable and high quality chemistry service providers in the world, BioDuro has the scientific expertise to support a vast range of discovery projects. Our years of experience in working with the world’s biggest pharmaceutical companies and most progressive biotech startups assist us in enhancing our partners’ discovery campaigns. With state-of-the art facilities and a team of over 500 dedicated scientists we are ready to support your efforts in these areas.

BioDuro Advantage

  • Strong operational support for material sourcing and compound management
  • Every chemist has access to SciFinder
  • State-of-the-art equipment
  • Responsive project management
  • Broad therapeutic disease area expertise

Services

  • Hit identification
  • Hit-to-lead chemistry
  • Lead optimization and preclinical candidate selection
  • Compound scale-up & purification

Medicinal Chemistry

Benefitting from a team of senior level scientists with experience leading projects in Big Pharma and Biotech where they successfully moved compounds into development, BioDuro’s Medicinal Chemistry team has helped its partners from hit identification to pre-clinical compound selection. Our team is capable of handling projects across a broad range of target families and therapeutic areas.

BioDuro Advantage

  • Deep integration with drug discovery teams
  • Sophisticated interpretation of biological data to inform compound design
  • Problem solving expertise and creativity
  • Responsive project management and clear communication
  • Broad therapeutic disease area expertise
  • Experienced in patent busting and patenting strategies

Services

  • Hit selection
  • Hit to lead chemistry
  • Multi-parameter lead optimization to Target Product Profile
  • Patent preparation and filing

Synthetic Chemistry

BioDuro is proud of its record in synthesizing quality compounds at rapid speed. We are skilled at tackling complex synthetic routes with ease and on scales ranging from milligrams to kilograms. BioDuro has conducted a broad range of chemistry projects ranging from design and synthesis of biologically relevant heterocyclic systems through asymmetric synthesis, peptide chemistry, nucleoside chemistry and total synthesis of natural products.

BioDuro Advantage

  • Independent route design to complex target molecules and timely execution
  • Problem solving expertise and creativity
  • Responsive project management and seamless communication
  • Broad synthetic and therapeutic area expertise
  • Strong IP protection and strategic planning

Services

  • Organic synthesis
    • Intermediate synthesis
    • Building block synthesis
    • Reference compound synthesis
    • Metabolite synthesis
    • Impurity synthesis
  • Bioorganic synthesis
    • Antibody drug conjugate synthesis
  • Process Discovery and Development
    • Reaction condition optimization
    • Route discovery, selection, and development
    • Impurity characterization and management
    • Reference standard preparation
  • Parallel chemistry
    • Hit expansion
    • SAR exploration
    • Focused libraries
  • Scale-up to non-GMP drug substance
    • Synthesis of up to 5 kg of final product

Computational Chemistry

In collaboration with medicinal chemists, computational chemists at BioDuro play an integral role in identifying and optimizing novel leads against selected therapeutic targets using various computational tools. Our computational team assists in the design of novel scaffolds and warheads for fragment-based screening. We use chemoinformatics and bioinformatics approaches to profile target selectivity and toxicity.

BioDuro Advantage

  • Deep integration with drug discovery teams
  • Problem solving expertise and creativity
  • Sophisticated interpretation of biological data
  • Responsive project management
  • Broad therapeutic disease area expertise
  • Experience in patenting strategies

Services

  • Small molecule modeling
  • Conformational analysis
  • ADME and physiochemical property prediction
  • Homology modeling
  • Library design, enumeration and diversity analysis
  • Ligand-based virtual screening
  • Development of QSAR models for hERG and CYP inhibition
  • Construct design and identification of amino acids for mutagenesis study

Capabilities

  • Linux workstation
  • 3D graphics room
  • Schrödinger modeling suite
  • Pipeline pilot
  • Spotfire
  • Pymol
  • Weblab viewer
  • Wincoot

Analytical Chemistry

Upon completion of synthesis, compounds undergo purification, rigorous characterization, analysis and structural determination by the analytical chemistry team. BioDuro’s analytical laboratories facilitate integrated and efficient project management with analytical scientist actively engaging with synthetic chemists. Equipped with state-of-the-art instruments and automation, BioDuro’s experienced analytical team ensures the quality of synthesized material and rapid turn-around time.

BioDuro Advantage

  • Dedicated team of trained analytical chemists
  • Close interaction with project teams
  • Flexible to meet project needs
  • Fast turnaround time
  • Reproducible high-quality data

Services

  • Method development
  • Routine purification
  • Chiral separation
  • Impurity analysis
  • Thermal analysis
  • Particle size, shape and crystallinity determination

Capabilities

  • Reverse phase chromatography by HPLC and UPLC
  • Chiral separation
  • Analytical and semi-prep SFC
  • LCMS analysis
  • GCMS analysis
  • NMR (1H, 13C, F, P nuclei, 1D and 2D experiments)
  • Optical rotation determination
  • Dissolution
  • Karl Fischer
  • Stability Testing
  • Physicochemical property test according to the USP and CHP
  • Residual solvent determination (GC-FID, ECD)
  • Thermal Analysis (DSC)
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