Let's talk
Contact us
Drug Discovery at BioDuro (Icon)


Drug discovery through advanced chemistry. Enhancing projects with cutting edge expertise in medicinal, synthetic, and computational chemistry.

Interested in our Chemistry expertise?

Contact us


With an established reputation as one of the most reliable and high-quality chemistry service providers in the world, BioDuro has the scientific expertise to support a vast range of discovery projects. Our years of experience in working with the world’s biggest pharmaceutical companies and most progressive biotech startups have enabled us in enhancing our partners’ discovery campaigns. With state-of-the art facilities and a team of over 500 dedicated chemists we are ready to support your efforts in these areas.

BioDuro Advantage

  • Strong operational support for material sourcing and compound management
  • Every chemist has unlimited access to SciFinder-n
  • State-of-the-art equipment
  • Responsive project management
  • Broad synthetic chemistry and therapeutic disease area expertise


  • Hit identification
  • Hit-to-lead chemistry
  • Lead optimization and preclinical candidate selection
  • Compound scale-up & purification


BioDuro is proud of its record in synthesizing quality compounds at rapid speed. We are skilled at tackling complex synthetic routes with ease and on scales ranging from milligrams to kilograms. BioDuro has conducted a broad range of chemistry projects ranging from design and synthesis of biologically relevant heterocyclic systems through asymmetric synthesis, peptide chemistry, nucleoside chemistry and total synthesis of natural products.

BioDuro Advantage

  • Independent route design to complex target molecules and timely execution
  • Problem solving expertise and creativity
  • Responsive project management and seamless communication
  • Broad synthetic and therapeutic area expertise
  • Strong IP protection and strategic planning


  • Organic synthesis
    • Intermediate synthesis
    • Building block synthesis
    • Reference compound synthesis
    • Metabolite synthesis
    • Impurity synthesis
  • Process Discovery and Development
    • Reaction condition optimization
    • Route discovery, selection, and development
    • Impurity characterization and management
    • Reference standard preparation
  • Parallel chemistry
    • Hit expansion
    • SAR exploration
    • Focused libraries
  • Scale-up of non-GMP drug substance
    • Synthesis of up to 5 kg of final product


Benefitting from a team of senior level scientists with experience leading projects in Big Pharma and Biotech where they successfully moved compounds into development, BioDuro’s Medicinal Chemistry team has helped its partners from hit identification to pre-clinical compound selection. Our team is capable of handling projects across a broad range of target families and therapeutic areas.

BioDuro Advantage

  • Deep integration with drug discovery teams
  • Sophisticated interpretation of biological data to inform compound design
  • Problem solving expertise and creativity
  • Responsive project management and clear communication
  • Broad therapeutic disease area expertise
  • Experienced in patent busting and patenting strategies


  • Hit selection
  • Hit to lead chemistry
  • Multi-parameter lead optimization to Target Product Profile
  • Patent preparation and filing


In collaboration with medicinal chemists, computational chemists at BioDuro play an integral role in identifying and optimizing novel leads against selected therapeutic targets using various computational tools. Our computational team assists in the design of novel scaffolds and warheads for fragment-based screening. We use cheminformatics and bioinformatics approaches to profile target selectivity and toxicity.

BioDuro Advantage

  • Deep integration with drug discovery teams
  • Problem solving expertise and creativity
  • Sophisticated interpretation of biological data
  • Responsive project management
  • Broad therapeutic disease area expertise
  • Experience in patenting strategies


  • Small molecule modeling
  • Homology modeling
  • MD-based protein conformational analysis
  • Diverse/focused library design, enumeration and analysis
  • Conformational analysis and comparison (QM/MM)
  • 2D/shape/pharmacophore/structure-based virtual screening
  • ADMET and physiochemical property prediction
  • 2D/3D Quantitative Structure-Activity/Property Relationship (QSAR/QSPR) model build
  • Construct design and identification of amino acids for mutagenesis study


  • Linux workstation
  • 3D graphics room
  • Schrödinger modeling suite
  • Spartan 18


Upon completion of synthesis, compounds undergo purification, rigorous characterization, analysis and structural determination by the analytical chemistry team. BioDuro’s analytical laboratories facilitate integrated and efficient project management with analytical scientist actively engaging with synthetic chemists. Equipped with state-of-the-art instruments and automation, BioDuro’s experienced analytical team ensures the quality of synthesized material and rapid turn-around time.

BioDuro Advantage

  • Dedicated team of trained analytical chemists
  • Close interaction with project teams
  • Flexible to meet project needs
  • Fast turnaround time
  • Reproducible high-quality data


  • Method development
  • Routine purification
  • Chiral separation
  • Impurity analysis
  • Thermal analysis
  • Particle size, shape and crystallinity determination


  • Reverse phase chromatography by HPLC and UPLC
  • Chiral separation
  • Analytical and semi-prep SFC
  • LCMS analysis
  • GCMS analysis
  • NMR (1H, 13C, F, P nuclei, 1D and 2D experiments)
  • Optical rotation determination
  • Dissolution
  • Karl Fischer
  • Stability Testing
  • Physicochemical property test according to the USP and CHP
  • Residual solvent determination (GC-FID, ECD)
  • Thermal Analysis (DSC)
Interested in our expertise?
Contact us for more information Get in touch