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Pharmacology

Comprehensive studies that elucidate pharmacodynamics, mechanism of action, and efficacy of candidate compounds. In vivo and in vitro studies are conducted with utmost care and compliance with best industry practice.

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Overview

BioDuro’s pharmacology team has extensive drug discovery and development experience in the pharmaceutical industry enabling us to support fully integrated programs, including study design and data interpretation. By working together closely, our chemists, discovery biologists, and drug metabolism and pharmacokinetics (DMPK) scientists are able to provide BioDuro clients a range of flexible service models including integrated programs, full time employee (FTE) services or fee-for-services (FFS).

BioDuro Advantage

  • Scientific staff with a broad range of educational backgrounds
  • Dedicated, collaborative project management
  • Versatility in animal handling, dosing and surgery
  • Integrated discovery programs

Services

  • Translational research
  • Biomarker discovery & development
  • Compound efficacy validation
  • Consultation

Capabilities (Therapeutic focus)

  • CNS
    • Mouse/rat BBB
    • Formalin-induced nociceptive response (Pain) model
  • Inflammation and Immunology Disease
    • LPS-induced cytokine secretion mice model
    • Topical arachidonic acid-induced inflammation mice model
    • Rodent collagen-induced arthritis (CIA) mice/rat models
    • Experimental Autoimmune Encephalomyelitis (EAE) mice models
    • OVA-induced asthma mice model
    • Pristane-Induced Lupus mice model
    • MRL/lpr genetic Lupus mice model
    • Intestinal Bowel Disease mice/rat model
    • Delayed Type Hypersensitivity (DTH) mice model
    • FITC Induced Dermatitis mice model
    • Imiquimod-induced psoriasis mice model
    • Bleomycin-induced pulmonary fibrosis in mice model
    • Citric Acid Induced Cough in Guinea-pig model
  • Metabolic Disease
    • Compound efficacy validation
      • Glucose homeostasis
      • Energy homeostasis
      • Grip strength and coordination
    • Metabolic diseases animal models
      • High fat diet induced obese (DIO) rats/mice
      • Streptozotocin (STZ) induced type 1 diabetic rats/mice
      • High fat diet (HFD) + STZ induced type 2 diabetic rats/mice
      • KKAy mice with NASH, retinopathy, nephropathy
      • ob/ob and db/db mice
      • GK (Goto-Kakizaki ) rats
      • ApoE KO mice
      • Myocardial infarction and reperfusion injury in rats/mice
      • Renal ischemia and reperfusion injury in rats/mice
    • In Vivo Assays
      • Oral/intraperitoneal glucose, insulin and pyruvate tolerance tests
      • Glucagon challenge tests
      • Hyperinsulinemic-euglycemia clamp
      • Hyperglycemia clamp
      • Energy expenditure indirect calorimetry system (TSE)
      • Infrared locomotor activity monitoring
      • Food intake and Water intake monitoring
      • Urine and feces collection
      • Treadmill exercise
      • Body composition analysis (MRI)
      • Grip strength
      • Coordination (Rotarod)
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