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Oncology

Combining classic and cutting-edge in vitro and in vivo research to support drug discovery efforts for cancer treatment.

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Overview

BioDuro’s Oncology department is committed to providing high quality preclinical services to support anti-cancer drug discovery in 2D and 3D cellular models and animal tumor models. With an experienced scientific team and a panel of validated assays and cancer animal models, we assist pharmaceutical companies and academic researchers in the discovery of novel drug targets and evaluation of anti-cancer compounds or biologicals.

BioDuro Advantage

  • Experienced scientific team with a strong background in cancer biology
  • Combination of classic and cutting-edge cancer research models and platforms
  • Dedicated and collaborative project management
  • High quality, time and cost efficient services to clients
  • Advanced laboratory equipment and a state of the art AAALAC accredited vivarium
  • Integrated drug discovery solutions with Medicinal Chemistry, DMPK, and Formulation Development.

Services

  • Oncology therapeutic target discovery and validation
  • Compound and biologics efficacy and early safety evaluation
  • Consultation
  • Oncology drug discovery

Capabilities

  • Cellular model based assays:
    • Cancer cell 2D culture, 3D spheroid culture, and the hTME-3DX Screen and Verify  (a sophisticated, more physiologically relevant 3D model recapitulating the patient tumor microenvironment)
    • Drug target discovery and validation: RT-PCR, western blot, IHC, FACS, ELISA, siRNA/shRNA, CRISPR
    • Drug efficacy evaluation: enzymatic and biochemistry assays, cell proliferation assay (MTT, CTG, Brdu, Alarma blue)
    • Cancer cell apoptosis, migration, invasion assays
  • Cancer animal models:
  • Immuno-oncology:
    • PBMC, B, T, NK cell isoloation
    • T and NK cells activation and proliferation
    • Immuno-phenotyping with multi-color FACS
    • Immunocytes and cytokine infiltration assay in 3D tumor cell spheroids
    • Multiplex cytokine analysis , MSD
    • PBMC and NK cells mediated cytotoxicity
    • Antibody dependent cell-mediated cytotoxicity assay with multiple assay formats
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